Simulation study of a simultaneous beta-gamma-ray detection using a 3-layer phoswich detector and Monte Carlo methods.

Combination of two or three dissimilar scintillator materials as a radiation detector has found major role in environmental radiation monitoring. In this paper, a three-layer Phoswich detector including BC-400, YAG, and CsI was designed to efficiently discriminate gamma-ray in the beta events up to 3.2 MeV using a simple rise-time discrimination method. MCNPX Monte Carlo code was used to obtain interaction probability of beta and gamma-rays as well as optimum thicknesses of the layers in the designing process. The optical transport of the system was simulated by GEANT4. In this regard, the pulses from simultaneous beta-gamma emitter sources were detected and discriminated based on pulse's rise-time so that the minimum number of gamma-ray contaminating events was observed in the beta spectrum. The results showed that using the proposed configuration and the method, output pulses with a rise-time shorter than 9 ns have been successfully detected as a beta particle while those with rising time longer than 15 ns have been identified as gamma-ray events. Overall results revealed that using the proposed system, an individual spectrum of beta particles or gamma-rays can be recorded from a simultaneous beta-gamma emitter source that minimizes contribution of the other radiation.

WO3/Ag/ZnO S-scheme heterostructure thin film spinning disc photoreactor for intensified photodegradation of cephalexin antibiotic.

The presence of antibiotics in wastes and drinking water has led to serious environmental and health concerns, further necessitating the development of an advanced sustainable strategy to eliminate antibiotics from aquatic media. In this context, the present research reports the successful fabrication of a spinning disc photoreactor (SDPR) supported ZnO/Ag/WO3 S-scheme visible-light-driven thin-film photocatalyst to study the degradation of cephalexin (CPX) as a target pollutant under blue light irradiation. The optical, electrochemical and physicochemical characterization of the as-prepared thin-film samples were carried out by XRD, top-view FE-SEM, EDS-mapping, UV-Vis-DRS, contact angle, EIS, transient photocurrent, mott Schottky and AFM techniques. The rod shape morphology of the samples with moderate surface roughness, desirable hydrophobicity, low bandgap and remarkable band structure alignment confirmed the applicability of as-prepared thin-film with an average photon flux of 1.94 × 10-4-8.61 × 10-5 E's m-2 s-1. The use of a rotating catalytic disc impressively declined the photon propagation distance, decremented the probability of light absorption by the solution, and intensified the mass transfer rate. The maximum throughputs of 98.8% efficiencies for CPX degradation were achieved at a rotational speed of 180 rpm, the solution flow rate of 1.0 L min-1, the light intensity of 11 mW cm-2, and initial CPX concentration of 40 mg L-1, illumination time of 80 min, and pH of 6. Damkohler number (Da) value was found to be 1.23 × 10-2 at the optimum conditions, indicating the negligibility of the external mass transfer resistance in the SDPR. The photocatalytic mechanism was elucidated for finding the most operative radical species, suggesting the crucial role of ·O2- in photodegradation of CPX and a drastic improvement of the charge separation by S-scheme heterostructure and facilitation by Ag mediator. Findings indicated that the developed reusable and robust SDPR benefited from an s-scheme photocatalyst can be a promising technology for degradation of the organic compounds.

Spinning disc photoreactor based visible-light-driven Ag/Ag2O/TiO2 heterojunction photocatalyst film toward the degradation of amoxicillin.

The presence of antibiotics in waste and drinking water is causing increasing concern around the world, thereby an advanced sustainable technology needs to be developed to eliminate the antibiotics from water resources. Hence, an efficient spinning disc photoreactor (SDPR) equipped with visible light-activated Ag/Ag2O/TiO2 heterostructure thin film photocatalyst was assessed for the degradation of amoxicillin (AMX) as a typical antibiotic. The surface morphology, optoelectronic and structural features of Ag/Ag2O/TiO2 heterojunction were characterized by TEM, BET, mott Schottky, FESEM, EDS, AFM, XRD, UV-Vis-DRS, and contact angle measurements. Results confirm that Ag and Ag2O have a significant effect on the photocharge carrier separation and transfer of the as-developed photocatalyst system. The operative variables including illumination time, rotational speed, solution flow rate, aeration rate, pH, and initial AMX concentration were optimized by CCD. The results displayed the maximum AMX photodegradation (97.91%) could be achieved at optimal conditions involving illumination time of 80 min, a rotational speed of 225 rpm, the solution flow rate of 0.6 L/min, aeration rate of 20 L/min, pH = 6, and initial AMX concentration of 20 mg/L. Interestingly, more than 79% COD and 64% TOC were removed under optimum conditions during 80 min illumination time, respectively. Active species tests confirmed the dominant role of ·OH and ·O2- in AMX degradation. finally, the XRD pattern confirmed that the reusability assessments of the heterojunction film could successfully retain its stability for six consecutive photocatalytic degradation runs. This work demonstrates the feasibility of utilizing visible-light-driven thin-film photocatalysts in spinning disc photoreactors in treating the tenacious antibiotic pollutants.

Renoprotective effects of prazosin on ischemia-reperfusion injury in rats.

BACKGROUND: Renal ischemia-reperfusion (IR) injury is one of the main leading causes of acute kidney injury associated with inflammation, oxidative stress and cell apoptosis. We studied the effects of prazosin, as a specific blocker of α1-AR, on renal IR injury. METHODS: Rats were divided into normal control; untreated IR and prazosin-treated IR (1 mg/kg body weight). Prazosin was administered by intraperitoneal injection 30 min prior to IR induction. The level of urea/creatinine and oxidative factors were detected by colorimetric methods. Apoptosis-associated factors, inflammatory, and signaling proteins were analyzed in renal tissue. The abnormalities of renal histopathology were detected by immunohistochemistry. RESULTS: Administration of prazosin to IR rats ameliorated serum urea and creatinine and IR-induced histopathological damages. Lipid peroxidation was significantly improved after treatment by prazosin in IR injury rats, however, antioxidant status was not affected. Rats subjected to IR injury activated Bax protein and NF-κB mediated inflammatory response. Moreover, treatment with prazosin inhibited renal NF-κB activation, resulting in a significant decline in pro-inflammatory cytokine of IL-6. CONCLUSION: These findings suggest that prazosin could be a good candidate to attenuate renal IR injury due to its ability to modulate renal function, apoptosis and inflammation.

Monitoring udder health status using somatic cell counts in Holstein dairy herds located in north-east of Iran and effectiveness of 10-point mastitis control program.

BACKGROUND: The somatic cell count (SCC) of individual cow samples is a useful proxy for monitoring udder health status. AIMS: The present study aimed to provide updated information about udder health in Iranian Holstein dairy cattle, and to quantify the effectiveness of the mastitis control program. METHODS: A total of 17,990 monthly test-day records from 1,663 Holstein dairy cattle in 10 "regular" herds and 2,389 test-day records from 386 Holstein dairy cattle in 2 herds that were assigned to the 10-point mastitis control program ("controlled" herds) were included. Each test-day record comprised the date of recording, daily milk production (kg), fat and protein (%), days in milk, parity, and SCC. RESULTS: Median (Q1-Q3) SCC × 103 for "regular" and "controlled" herds were 136 (52-391) and 64 (24-204) cells/ml, respectively. Also, the percentage of records containing SCC >200,000 cells/ml (elevated SCC) for these groups were 40.3% and 25.5%, respectively. Mixed effects logistic analysis revealed that milk records from cows in the first lactation, early lactation, and with >40 kg daily milk yield had lower odds of elevated SCC. The odds of elevated SCC were lower in summer and autumn than in winter. CONCLUSION: Host and environmental characteristics influence SCC. This should be considered for the interpretation of SCC results. Mastitis control programs can support dairy producers to reach a standard level of udder health.

Emerging salt marshes as a source of Trichoderma arenarium sp. nov. and other fungal bioeffectors for biosaline agriculture.

AIMS: Sustainable agriculture requires effective and safe biofertilizers and biofungicides with low environmental impact. Natural ecosystems that closely resemble the conditions of biosaline agriculture may present a reservoir for fungal strains that can be used as novel bioeffectors. METHODS AND RESULTS: We isolated a library of fungi from the rhizosphere of three natural halotolerant plants grown in the emerging tidal salt marshes on the south-east coast of China. DNA barcoding of 116 isolates based on the rRNA ITS1 and 2 and other markers (tef1 or rpb2) revealed 38 fungal species, including plant pathogenic (41%), saprotrophic (24%) and mycoparasitic (28%) taxa. The mycoparasitic fungi were mainly species from the hypocrealean genus Trichoderma, including at least four novel phylotypes. Two of them, representing the taxa Trichoderma arenarium sp. nov. (described here) and T. asperelloides, showed antagonistic activity against five phytopathogenic fungi, and significant growth promotion on tomato seedlings under the conditions of saline agriculture. CONCLUSIONS: Trichoderma spp. of salt marshes play the role of natural biological control in young soil ecosystems with a putatively premature microbiome. SIGNIFICANCE AND IMPACT OF THE STUDY: The saline soil microbiome is a rich source of halotolerant bioeffectors that can be used in biosaline agriculture.

Hemodynamic Changes and Early Recovery of Liver Graft Function after Liver Transplantation.

BACKGROUND: Patients with liver cirrhosis experience a hyperdynamic circulation. OBJECTIVE: To investigate the association between early hemodynamic changes and graft function after liver transplant. METHODS: Those patients who underwent liver transplantation in 2016 were enrolled in the study. Liver function indices measured in postoperative days (POD) 1, 3, 5, 7, 9, and 11 along with hemodynamic indices including pulse rate, systolic blood pressure (SBP), diastolic blood pressure (DBP), and central venous pressure (CVP) measured q6h in the first 3 days after transplantation were recorded. RESULTS: 57 deceased-donor liver recipients with a mean±SD age of 41.4±11.8 years including 33 (58%) males were enrolled in the study. The mean±SD aspartate and alanine aminotransferases, alkaline phosphatase, and lactate dehydrogenase were significantly decreased from 1879±670.5, 369.2±40.5, 174.9±18.8, and 1907.6±323.1 U/L in POD 1 to 37.2±10.7, 243.4±37.3, 207.5±19.5, and 382.4±59.8 U/L in POD 3, respectively (p=0.028, <0.001, 0.002, and 0.001, respectively). During this period, the pulse rate of the patients was significantly (p<0.001) decreased by a median (IQR) of 28.7 (8.5-39.7) beats/min; it was significantly correlated with a decrease in serum hepatic enzymes activities during this period. SBP, DBP, and CVP were significantly increased (p<0.001 for all) during this period. Liver graft function improved significantly earlier in those patients with a mean pulse rate of 87 beats/min compared with others (p=0.03). CONCLUSIONS: There may be an association between changes of hemodynamic indices, especially reduction of pulse rate, and improved graft function early after liver transplantation.

Case report: Xanthogranulomatous pyelonephritis masquerading as cystic renal cell carcinoma.

Background: Xanthogranulomatous pyelonephritis (XGP) is a rare chronic bacterial inflammation of the renal parenchyma and is often a diagnostic dilemma.Case Presentation: We present a challenging case of a patient with XGP. Initially thought to have had renal cell cancer she was treated accordingly with a partial nephrectomy. However, on the final pathology, she was found to have XGP and required further antibiotic therapy and referral to the infectious disease service.Discussion: Management of XGP and diagnostic pitfalls are discussed.Conclusion: XGP is a diagnostic and therapeutic dilemma. Partial Nephrectomy may be appropriate in management of XGP in select cases.

Impact of stabilizer on the environmental behavior of PVC films reinforced 1,2,4-triazole moiety.

A new Schiff base containing 1,2,4-triazole ring system (L) was synthesized and confirmed by 1HNMR, FTIR spectroscopy. The chemical modification of PVC with a new Schiff base (L) was synthesized to produce a homogenous blend (PVC-L). A homogenous blend (PVC-L) was added to copper chloride to produce PVC-L-Cu (II). The PVC films had been irradiated with ultraviolet light for a long period and confirmed by FTIR spectroscopy and weight loss; the surface morphology was inspected by scanning electron microscopy.

The effect of high UV radiation exposure environment on the novel PVC polymers.

Although plastic induces environmental damages, almost the consumption of poly(vinyl chloride) never stops increasing. Therefore, this work abstracted by two parts, first, synthesis of Schiff bases 1-4 compounds through the reaction of amino group with appropriate aromatic aldehyde, reaction of PVC with Schiff bases compounds 1-4 in THF to form a new modified PVC-1, PVC-2, PVC-3, and PVC-4. The structures of Schiff bases 1-4 and the modified PVC-1, PVC-2, PVC-3, and PVC-4 have been characterized by different spectroscopic analyses. Second, the influence of introducing 4-amino-1,2,4-triazole as a pendent groups into PVC chain investigated on photostability rules of tests. The modified polymers photostability investigated by observing indices (ICO, Ipo, and IOH), weight loss, UV and morphological studies, and all results obtained indicated that PVC-1, PVC-2, PVC-3 and PVC-4 gave lower growth rate of ICO, IPO, and IOH through UV exposure time. The photostability are given as PVC-4 < PVC-3 < PVC-2 < PVC-1 from different mechanisms which suggested building on existence of 4-amino-1,2,4-triazole moieties in the polymer chain.

Influence of Mg/CTAB ratio on the structural, physicochemical properties and catalytic activity of amorphous mesoporous magnesium silicate catalysts.

This study investigated the physicochemical and catalytic properties of mesoporous magnesium silicate catalysts prepared at various Mg/CTAB ratios (0.25, 0.50, 0.75 and 1.00). The XPS analysis detected a mixture of enstatite and magnesium carbonate species when the Mg/CTAB ratio was 0.25, and 0.50. A mixture of forsterite and magnesium carbonate species were detected when the Mg/CTAB ratio was 0.75 whereas for the Mg/CTAB ratio of 1.00, enstatite and magnesium metasilicate species were detected. A catalyst with the Mg/CTAB ratio of 1.00 demonstrated the highest catalytic activity in the oxidation of styrene. The styrene conversion rate was 59.0%, with 69.2% styrene oxide (StO) selectivity. The H2O2 molecules were activated regio-specifically by the magnesium species to prevent rapid self-decomposition while promoting selective interaction with styrene. All the parameters that influence the styrene conversion and product selectivity were evaluated using analysis of variance (ANOVA) with Tukey's test. The ANOVA analysis showed that the reaction time (h), Mg/CTAB ratio, styrene/H2O2 ratio, catalyst loading (mg) and temperature (°C) affect styrene conversion and product selectivity (StO) significantly (p < 0.05). The oxidation of styrene was well fitted to the pseudo-first-order model. The activation energy, E a of the catalysed styrene epoxidation reaction was calculated to be 27.7 kJmol-1. The catalyst can be reused several times without any significant loss in its activity and selectivity. The results from this study will be useful in designing and developing low cost, high activity catalysts from alkaline earth metals.

SYNTHESIS, OPTICAL PROPERTIES AND THERMOLUMINESCENCE DOSIMETRY FEATURES OF MANGANESE DOPED Li2B4O7 NANOPARTICLES.

Lithium tetraborate (Li2B4O7) nanoparticles (NPs) doped with manganese (Mn) were prepared for the first time by the solid-state sintering method. NPs were characterized using X-ray diffraction, scanning electron microscopy, photoluminescence and thermoluminescence (TL) techniques. The synthesized NPs exhibited highest TL response at 0.3 wt% of Mn dopant under gamma irradiation. TL dose response is linear for the absorbed dose from 1 Gy to 20 kGy and beyond this range behaves sub-linear. Such feature makes the synthesized nanophosphor as a promising material for high-dose dosimetry applications. Low fading and good reusability were obtained for the synthesized NPs. Tm-Tstop and computerized glow curve deconvolution procedures were utilized to identify the component TL glow peaks and kinetic parameters of the produced phosphor. Other TL dosimetry features of the prepared NPs are also presented and discussed.

Effects of black seed (Nigella sativa), ginger (Zingiber officinale) and cone flower (Echinacea angustifolia) on the immune system of rainbow trout, Oncorhynchus mykiss / Efeitos de semente preta (Nigella sativa), gengibre (Zingiber officinale) e Flor-de-cone (Echinacea angustifolia) no sistema imunológico de truta arco-íris, Oncorhynchus mykiss

This study was carried out to evaluate the effects of dietary essential oils of ginger (Zingiber officinale), black seed (Nigella sativa) and cone flower (Echinacea angustifolia) on the immune system of cultured rainbow trout, Oncorhynchus mykiss. A total of 360 fish were divided into 4 groups and 3 replicates each containing 30 fish. The fish were fed for 21 days with 1% of the herbal essential oils and with unsupplemented diet as the control group. Haematological and immune parameters including serum lysozyme, number of phagocytic bacteria, Hb, PCV, MCV, MCH, MCHC, number of RBC and WBC were studied. Treatments recorded enhancement in immune parameters compared to the control group. Significantly higher serum lysozyme level and phagocytic germs were detected in the groups fed black seed, ginger and cone flower (P<0.05). However, no significant difference was found in RBC, Hb, PCV, MCV, MCH and MCHC of fish fed the diets containing essential oils and the control group (P>0.05). The results of this study demonstrated that essential oils might strengthen the non-specific immunity of rainbow trout.(AU)

Avaliou-se a eficácia de uma dieta com semente preta (Nigella sativa), gengibre (Zingiber officinale) e Flor-de-cone (Echinacea angustifolia) sobre o sistema imunológico de truta arco-íris (Oncorhynchus mykiss) em cultivo. Um total de 360 peixes foram divididos em 4 grupos com 3 repetições cada, contendo 30 peixes. Os peixes foram alimentados por 21 dias com 1% de óleo essencial herbáceo e com dieta comercial não suplementada como controle. Parâmetros imunes e hematológicos incluindo soro lisozima, número de bactéria fagocítica, Hb, PCV, MCV, MCH, MCHC, número de RBC e WBC foram estudados. Os tratamentos registraram a melhoria em parâmetros imunes comparados ao grupo de controle. Foram detectadas concentrações de lisozima no soro e germes fagocíticos significativamente altos em grupos que receberam semente preta, gengibre e Flor-de-cone (P<0.05). Porém, não foi encontrada diferença significativa em RBC, Hb, PCV, MCV, MCH e MCHC nos peixes alimentados com dietas contendo óleos essenciais e no grupo de controle (P>0.05). Os resultados deste estudo demonstraram que óleos essenciais podem aumentar a imunidade não específica da truta arco-íris.(AU)

Evaluation of the immune response in BALB/c mice induced by a novel DNA vaccine expressing GRA14 against Toxoplasma gondii.

Toxoplasma gondii can cause severe and even fatal disease in human beings and animals. Effective vaccines may contribute to control toxoplasmosis. GRA14, a novel secreted dense granule protein of T. gondii, has been proposed as a vaccine candidate due to its intervacuolar transport and unique topology in the parasitophorous vacuole membrane. In this study, we constructed a DNA vaccine encoding GRA14 of T. gondii. BALB/c mice were immunized intramuscularly three times at 2 week intervals and challenged with T. gondii RH strain 5 weeks later. The immune responses were evaluated using lymphocyte proliferation assay, cytokine and antibody measurements. In addition, the survival times and parasite load of mice challenged with the virulent T. gondii RH strain were evaluated. The results showed that the mice immunized with pcGRA14 induced both enhanced specific humoral and Th1 cellular immune responses, and also mice immunized with the pcGRA14 showed an increased survival time and decreased parasite load compared with control groups (P<.05). The results indicated, for the first time, that the GRA14 is a potential DNA vaccine against toxoplasmosis.

Association of SRD5A2 gene mutations with risk of hypospadias in the Iranian population.

BACKGROUND: Hypospadias is one of the most common forms of congenital malformation of the male external genitalia worldwide. The ratio in the Iranian population is one in 250 live male births. The conversion of testosterone to dihydrotestosterone (DHT) in the presence of steroid 5α-reductase 2, which is encoded by SRD5A2 gene, plays an important role in the normal development of the male reproductive system. METHODS: We examined whether SRD5A2 gene mutations (V89L and A49T polymorphisms) are associated with the risk of hypospadias in the Iranian population. We performed exons sequencing for SRD5A2 gene in 109 hypospadias patients. RESULTS: We identified two new mutations in the subgroups of affected cases: including a substitution of the nucleotide T > A in the codon 73 [c.219T > A (p.Leu73_Ser74insHisPro)] and an insertion of an extra A nucleotide in the codon 77 [c.229insA* (p.Gly77*)]. Additionally, we performed PCR-RFLP for the two identified polymorphisms and revealed that V89L [OR = 5.8, 95% CI (3.8-8.8), p value < 0.001] and A49T [OR = 10.16, 95% CI (3.94-26.25), p value < 0.001] are significantly associated with hypospadias occurrence in patients. Our haplotype analysis further indicated that the Leu-Ala haplotype increases risk of hypospadias; conversely, the Val-Ala haplotype decreases the risk of hypospadias in the studied patients. CONCLUSIONS: This study demonstrates that polymorphisms in the SRD5A2 gene could be considered as a risk factor for hypospadias disease emergence.

Copper Catalysis in Living Systems and In†Situ Drug Synthesis.

The copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction has proven to be a pivotal advance in chemical ligation strategies with applications ranging from polymer fabrication to bioconjugation. However, application in vivo has been limited by the inherent toxicity of the copper catalyst. Herein, we report the application of heterogeneous copper catalysts in azide-alkyne cycloaddition processes in biological systems ranging from cells to zebrafish, with reactions spanning from fluorophore activation to the first reported in situ generation of a triazole-containing anticancer agent from two benign components, opening up many new avenues of exploration for CuAAC chemistry.

Sonophotocatalytic degradation of trypan blue and vesuvine dyes in the presence of blue light active photocatalyst of Ag3PO4/Bi2S3-HKUST-1-MOF: Central composite optimization and synergistic effect study.

An efficient simultaneous sonophotocatalytic degradation of trypan blue (TB) and vesuvine (VS) using Ag3PO4/Bi2S3-HKUST-1-MOF as a novel visible light active photocatalyst was carried out successfully in a continuous flow-loop reactor equipped to blue LED light. Ag3PO4/Bi2S3-HKUST-1-MOF with activation ability under blue light illumination was synthesized and characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray (EDX), photoluminescence (PL) and diffuse reflectance spectra (DRS). The effect of operational parameters such as the initial TB and VS concentration (5-45mg/L), flow rate (30-110mL/min), irradiation and sonication time (10-30min), pH (3-11) and photocatalyst dosage (0.15-0.35g/L) has been investigated and optimized using central composite design (CCD) combined with desirability function (DF). Maximum sonophotodegradation percentage (98.44% and 99.36% for TB and VS, respectively) was found at optimum condition set as: 25mg/L of each dye, 70mL/min of solution flow rate, 25min of irradiation and sonication time, pH 6 and 0.25g/L of photocatalyst dosage. At optimum conditions, synergistic index value was obtained 2.53 that indicated the hybrid systems including ultrasound irradiation and photocatalysis have higher efficiency compared with sum of the individual processes.

Assessment of the price-efficacy relationship for multiple brands of ceftriaxone sodium in Kabul: a cross-sectional study.

BACKGROUND: Most medicines are imported for health service practices in Afghanistan. A major concern for patients and practitioners in Kabul is the wide brand assortment and price range choices for the same drug. Ceftriaxone sodium is a broadly used antibiotic for infections caused by certain types of gram-positive and gram-negative bacteria. It is available in Kabul in a range of brands and prices. The objective of this study was to assess the relationship between cost/brand name and efficacy of this antibiotic. METHODS: 40 brands of ceftriaxone, obtained from Kabul's main pharmacy, were derived from 12 countries including Pakistan, Turkey, India, and China. Ten samples/brand were tested for efficacy by the minimal bactericidal concentration assay against a sensitive strain of Staphylococcus aureus according to the Clinical Institute and Laboratory Standards Protocols. Efficacy data were obtained by inoculating suspensions of S. aureus grown in Mueller-Hinton medium with various concentrations (6.25-800 mcg/ml) of each brand followed by incubation at 37 °C for 18-24 h. Aliquots of inoculated cultures were transferred to agar plates, incubated at 37 °C for 18-24 h and visible colonies counted. Results were analyzed using ANOVA, Student's t test, and Pearson correlation by SPSS 19. A p value ≤ 0.05 was considered statistically significant. RESULTS: Ceftriaxone sodium price varied from 20-270 Afghanis/brand (average price = 69.80 Afghanis/brand). Of the 40 brands tested, 10 (25 %) were not registered with the General Directorate of Pharmaceutical Affairs of the Ministry of Public Health in Afghanistan. More importantly, we observed no statistically significant difference in efficacy against S. aureus among these brands (p = 0.59). CONCLUSIONS: Our study showed no significant correlation among price, brand, and efficacy of ceftriaxone sodium against S. aureus, an important consideration when treating S. aureus infection in Afghanistan and elsewhere. Differences in brand prices are likely due to other factors including manufacturing and exportation costs, regulations of good manufacturing practice and seller's profit ceiling and patient preferences. Based on our results, we suggest that further chemical and clinical studies of ceftriaxone sodium brands are warranted and recommend that physicians consider alternative cost-effective generic brands in patient prescriptions.

Zeolite Nanoparticles for Selective Sorption of Plasma Proteins.

The affinity of zeolite nanoparticles (diameter of 8-12 nm) possessing high surface area and high pore volume towards human plasma proteins has been investigated. The protein composition (corona) of zeolite nanoparticles has been shown to be more dependent on the plasma protein concentrations and the type of zeolites than zeolite nanoparticles concentration. The number of proteins present in the corona of zeolite nanoparticles at 100% plasma (in vivo state) is less than with 10% plasma exposure. This could be due to a competition between the proteins to occupy the corona of the zeolite nanoparticles. Moreover, a high selective adsorption for apolipoprotein C-III (APOC-III) and fibrinogen on the zeolite nanoparticles at high plasma concentration (100%) was observed. While the zeolite nanoparticles exposed to low plasma concentration (10%) exhibited a high selective adsorption for immunoglobulin gamma (i.e. IGHG1, IGHG2 and IGHG4) proteins. The zeolite nanoparticles can potentially be used for selectively capture of APOC-III in order to reduce the activation of lipoprotein lipase inhibition during hypertriglyceridemia treatment. The zeolite nanoparticles can be adapted to hemophilic patients (hemophilia A (F-VIII deficient) and hemophilia B (F-IX deficient)) with a risk of bleeding, and thus might be potentially used in combination with the existing therapy.